Valencia's interim coach Voro spoke ahead of the visit of Barcelona.
Gary Neville will replace Nuno Espirito Santo from Sunday but for now Voro is in charge, with Phil Neville assisting.
Valencia come into the game in bad shape, with many injuries and only 15 players training on Friday.
"We are playing a great side, one of the best in the world and furthermore one that is in excellent form," said Voro.
"If it was difficult to beat them beforehand, now with the circumstances we find ourselves in with so many injuries.
"But that's the reality. Not so much for the quality of the opposition but because of the number of players we have missing."
Lucas Orban, Diego Alves, Shkodran Mustafi, Rodrigo, Sofiane Feghouli, Andre Gomes, Alvaro Negredo and Antonio Barragan are out injured, while Joel Cancelo and Javi Fuego are suspended.