Barcelona coach Ronald Koeman has rung the changes for the game against Getafe on Saturday.
Koeman made limited changes in the first three league games of the season but has made four for the game in Madrid this weekend.
Sergino Dest comes in for his full debut at left-back in place of the injured Jordi Alba, while Clement Lenglet, back from suspension, replaces Ronald Araujo at centre-back.
There are also two changes in the attack, with both Philippe Coutinho and Ansu Fati dropping to the bench following the international break.
Into the side come Pedri, still just 17, and Ousmane Dembele. Both are making their first starts of the season.
They join a four-man attack which also includes Antoine Griezmann and Lionel Messi.
Barça have won two and drawn one of their three games in La Liga so far this season.
Here's the team to face Getafe: Neto; Sergi Roberto, Piqué, Lenglet, Dest; Busquets, Frenkie de Jong, Griezmann, Pedri, Dembélé and Messi.