Barcelona kick off their Copa del Rey tie away against Cornella in the last 32 on Thursday.
The third division Barcelona-based side knocked out Atletico Madrid in the last round so won't be a walk over.
Barça coach Ronald Koeman has rested Frenkie de Jong and Jordi Alba, while Lionel Messi is suspended.
Gerard Pique, Sergi Roberto, Ansu Fati, Philippe Coutinho and Sergiño Dest are all missing injured.
In addition, Marc-Andre ter Stegen starts on the bench, with Neto handed a rare start in goal.
Koeman has handed a debut to 18-year-old B team midfielder Ilaix Moriba, while Riqui Puig also makes his first start of the season.
Francisco Trincao comes in to the attack, alongside Antoine Griezmann and Martin Braithwaite, with Konrad de la Fuente and Alex Collado left on the bench.
Barça side: Neto; Mingueza, Araujo, Lenglet, Junior; Pjanic, Ilaix, Riqui Puig; Trincao, Braithwaite & Griezmann.
Substitutes: Ter Stegen, Arnau Tenas; Umtiti; Sergio, Pedri, Matheus, Collado; Konrad, Dembélé.