Barcelona's 2-0 win at Sevilla on Saturday was tainted by a flurry of second-half injuries for Ronald Koeman's side.
Goals from Ousmane Dembele and Lionel Messi took Barça up to second in the table temporarily, but Pedri and Ronald Araujo were both taken off injured.
In the 70th minute, Pedri asked to come off after clashing with Sevilla's former Espanyol midfielder Joan Jordan.
Pedri, who overstretched while challenging for a high ball, quickly requested the change, with Koeman bringing on Ilaix Moriba in his place.
He watched the rest of the game from the bench with no ice on his leg, so bruising is ruled out, while he left the Sanchez Pizjuan on crutches.
Just 10 minutes later, Araujo was forced off having only come off the bench himself to replace Gerard Pique, who had agreed prior to the game to come off in the second half.
Araujo was making his first appearance since spraining his ankle vs. Real Betis and appeared to injure his ankle again here.
However, as Samuel Umtiti came on for him, the Uruguay international tried to come back on himself. Koeman didn't want to take any risks, though.
In anger at having to come off, Araujo kicked over a bench as he walked off the pitch.