Spain left it too late to force a comeback against a young England side on Monday in Seville, losing 3-2 at the Benito Villamarin.
De Gea, Jonny, Nacho, Ramos, Marcos Alonso, Busques, Thiago, Saúl (Alcácer, 56') , Aspas (Ceballos, 56'), Rodrigo (Morata, 72') y Asensio
Pickford, Trippier (Alexander-Arnold, 84'), Maguire, Gómez, Chilwell, Dier, Barkley (Walker, 74'), Winks (Clalobah, 89'), Sterling, Rashford y Kane
0-1, Sterling (16'); 0-2, Rashford (29'); 0-3, Sterling (37'); 1-3, Alcácer (57'); 2-3, Ramos (97')
Szymon Marciniak ((Polonia). TA: Ramos (64'), Jonny (75'), Ceballos (86'), Morata (97') / Dier (11'), Winks (64'), Maguire (61')
Benito Villamarín, 50.355 espectadores
Raheem Sterling scored either side of a Marcus Rashford effort as England soared into a three-goal lead at the break.
Substitute Paco Alcacer pulled one back for Spain in the second half and Sergio Ramos added a second in stoppage time, but Luis Enrique's side hadn't woken up in time.
Jordan Pickford made a fine early save from Marcos Alonso before Marco Asensio shot straight at the visiting goalkeeper as Spain started the better.
But England took the lead when Rashford fed Sterling in the 17th minute, the Manchester City star ending a three-year wait for an international goal.
England, well on top now, doubled their advantage when the brilliant Harry Kane set up Rashford on the half hour mark.
Kane was then the provider again eight minutes later, turning a fine Ross Barkley pass into the path of Sterling, who added his second of the night.
Luis Enrique's response was to bring on Paco Alcacer and Dani Ceballos after the break and Spain improved.
Alcacer scored within 90 second of coming on, his golden touch well intact as he flicked home from a corner. He has 10 goals in six games, the majority as a substitute, for club and country.
The referee then failed to spot Pickford's foul on Rodrigo, the England keeper lunging in on the Valencia forward after getting caught on the ball. Spain were furious not to get a penalty.
Still the hosts pressed but England stood strong. Alonso headed against the bar in stoppage time and Ramos got his goal in the 98th minute, the final whistle following swiftly after.
After three straight wins, Luis Enrique will now have to answer the first questions of his Spain career.