Mariano Diaz was absent from Real Madrid's final training session at Valdebebas and will not feature against Granada along with injured duo Marcelo and Nacho Fernandez.
Madrid have only Karim Benzema available up front in the centre with Luka Jovic also confined at home after having contact with a friend infected with coronavirus.
Madrid's squad had a light session with some ball exercises and shooting. They are saving their strength for the games - three matches in a week to decide the season.
Sergio Ramos and Dani Carvajal return from suspension and will come back into the side.