Paris Saint-Germain have confirmed on Sunday that Lionel Messi has tested positive for Covid-19 and will miss the cup game against Vannes.
Messi, 34, has just returned to Paris after spending the Christmas break back in his native Argentina with his family.
The former Barcelona forward is one of four PSG players to return a positive test result in the latest round of coronavirus testing at the Ligue 1 club.
"The 4 players that tested positive for Covid-19 are Leo Messi, Juan Bernat, Sergio Rico and Nathan Bitumazala," PSG said. "They are currently in isolation and are subject to the appropriate health protocol."
PSG are also still missing Neymar through injury,.
"Neymar will continue his treatment in Brazil until Jan. 9 with members of the Paris Saint-Germain medical and performance staff," the club added. "His return to training is still expected to be in about three weeks."