Sergio 'Kun' Aguero will make his full debut in Barcelona's game at Rayo Vallecano in LaLiga on Wednesday.
Aguero comes into the side in Madrid as one of a number of changes to the side that lost the Clasico 2-1 to Real Madrid on Sunday.
Several changes are forced, with Ansu Fati and Frenkie de Jong both missing out through injury, while Oscar Mingueza and Gavi also drop to the bench.
In addition to Aguero, Sergi Roberto, Nico Gonzalez and Philippe Coutinho all come into the side as Barça seek their first away win of the season.
It's Aguero's first start for Barça since he joined on a free transfer from Manchester City in the summer.
The Argentina international injured his calf in preseason and only returned to full training recently, appearing as a substitute in the last three games.
He scored his first goal for the club at the weekend, netting a late consolation in the defeat to Madrid at Camp Nou.
Barça side: Ter Stegen; Dest, Piqué, Eric Garcia, Alba; Busquets, Nico Gonzalez, Sergi Roberto; Memphis, Agüero, Coutinho.