Lyon have never beaten Barcelona in the Champions League. The two sides have clashed on six occasions and Barça have won four of them with the remaining two fixtures being draws. The Catalan giants have also scored 16 goals compared to Lyon's 7.
The first time FC Barcelona and Lyon met was in the group stages of the 2001/02 season. Barça won 2-0 at the Camp Nou and 3-2 in France.
The second clash also came in the group stages but of the 2007/08 season. Barcelona won 3-0 at the Camp Nou but could only draw 2-2 in Lyon.
They have only met once in the knockout rounds and it came in the Last 16 of the following season, 2008/09. Barça drew 1-1 in Lyon but then thumped the French team 5-2 at the Camp Nou. That Barcelona side, managed by Pep Guardiola, would later go on to win the competition.