Leo Messi has been Real Betis's nightmare over the years

Real Betis beat Barcelona at Camp Nou in November 2018, but are never happy when facing Leo Messi. The Barca captain, of the 10 teams he has faced most, has scored most against Real Betis - 1.04 goals per game. In 22 matches he has scored 23 goals.

Messi has scored seven doubles against Betis, the most along with Sevilla, and two-hat-tricks. And in three games, he has scored one goal.

The Argentine debuted against Betis backs in February 2006 with Barca's 5-1 win at Camp Nou. Messi came on in the 76th minute for Henrik Larsson and scored in the 85th off an Eto'o assist.