Gerard Pique picked up his fifth booking of the season against Sevilla and will be suspended for Barcelona's trip to Eibar after the international break.
The Barcelona centre-back was also booked in the first three matches of the season, against Athletic, Betis and Osasuna, and again against Granada.
He has also been booked twice in the Champions League, against Borussia Dortmund and Inter Milan, and is one booking away from a ban in Europe.
The fact he misses the Eibar game means, save injury, he will be available for the Clasico against Real Madrid on Oct. 26.
With Pique missing, Jean Clair Todibo may get to keep his place alongside Clement Lenglet, who will return from a suspension after the international break.
Samuel Umtiti is currently injured but should not be out for too much longer.