Barcelona were held to a second draw in LaLiga in a week as they drew 0-0 with Cadiz on Thursday.
Frenkie de Jong was sent off in the second half but Memphis Depay still had a chance to win it for Barça's 10 men late on.
At the other end, Marc-Andre ter Stegen had to be on top form to ensure Barça picked up their first clean sheet of the season.
The stalemate is unlikely to do Ronald Koeman any favours as the pressure on the Dutch coach grows.
Barça remain unbeaten through five games in LaLiga this season but they have drawn three of them, including their last two now against Granada and Cadiz.
Barça, who handed a full debut to 17-year-old Gavi, struggled to break Cadiz down in the first half but the game opened up after the break.
Ter Stegen kept out an Alvaro Negredo effort before Koeman's side took charge of the match.
Memphis should have done better when teed up by Luuk de Jong and minutes later brought a smart save out of Ledesma in the Cadiz goal.
However, the game changed when De Jong was dismissed for a second yellow card. His first yellow was for catching an opponent with his arm and his second, four minutes later, for a challenge in which he won the ball. The red was harsh.
That served to open the game up and both teams had chances to win it. Ter Stegen saved from Salvi and the best chance fell to Memphis in stoppage time.
Gerard Pique raced forward to supply the Dutch forward, but his shot was wide of the post.